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KMID : 0545120020120061017
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Journal of Microbiology and Biotechnology
2002 Volume.12 No. 6 p.1017 ~ p.1021
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In Vitro Bactericidal and Anticancer Activity of New Metabolite, ARK42, Isolated from Aspergillus repens K42
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PARK, JE WON
SONG, BEOM SEOK/RYU, DOJIN/LEE, CHAN/KIM, YOUNG BAE
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Abstract
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A novel antibacterial metabolite, ARK42, was isolated from a xerophilic fungal strain K42, and identified as Asperillus repens based on its morphological characteristic. The metabolite exhibited antibacterial activities towards Staphylococcus aureus, Bacillus cereus, and Pseudomonas aeruginosa, with MICs of 25, 12.5, and 3.125 ㎍/ml, respectively, and killed Pseudomonas aeruginosa with minimal bactericidal concentration (MBC) of 12.5 ㎍/ml. Furthermore, acticancer activities were demonstrated against human colon cancer DLD-1 and lung cancer LXFL529 cells with an IC_50 of 10 and 1 ㎍/ml, respectively.
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